Heidemarie Laurent's project title is "Maternal Depression Calibrates Infant's Neuroendocrine, Autonomic, and Inflammatory Stress Responsiveness." The purpose of this study is to determine how mothers’ depression calibrates their babies biological sensitivity to stress over time, and how this calibration translates into child emotional and behavioral problems. This will help to identify the roots of stress-related disorders and suggest targets for early intervention to interrupt the intergenerational transmission of stress-related health problems.