Biography
Steve Maren is a behavioral neuroscientist who specializes in the neurobiology of learning and memory in animal models. He has made several key discoveries to uncover the neurobiological basis of emotional learning and memory, particularly memory for fearful experiences. Each of these contributions has driven new empirical and theoretical work in the field and has been foundational to understanding the basic synaptic and circuit mechanisms underlying both normal and pathological fear memories. His primary research interests are neural systems for emotion, learning, and memory; contextual regulation of memory encoding and retrieval; and fear, anxiety, and PTSD. Research in his Emotion and Memory Systems Laboratory seeks to understand the brain circuits and cellular mechanisms underlying the encoding, storage, retrieval, and extinction of aversive memories, and how dysfunction in these circuits and processes contributes to anxiety disorders. We focus on the neurobiology of fear conditioning and extinction in rats and mice. The hippocampus, amygdala, and prefrontal cortex, a triad of interconnected brain areas with essential roles in memory and emotion, are critical for these processes. The lab uses both behavioral and systems neuroscience methods to understand the brain mechanisms of fear and anxiety. These approaches include calcium imaging, in vivo electrophysiology, and chemo- and optogenetics. Maren is a recipient of the American Psychological Association Distinguished Scientific Award for an Early Career Contribution to Psychology (2001) and the D. O. Hebb Distinguished Scientific Contributions Award (2017). He is also a Fellow of the American Psychological Association and Association for Psychological Science, Past-President of the Pavlovian Society, and a member of the scientific council of the Brain & Behavior Research Foundation. He has been continuously funded by the National Institutes of Health since 1995 and is a recipient of the 2015 McKnight Memory and Cognitive Disorders award. He started his research career as an undergraduate honors student in the Department of Psychology working with Dr. Michael Gabriel, first in the Psychology Building and later the Beckman Institute when it opened its doors in 1989. He went on to receive his doctorate in neurobiology from the University of Southern California in 1993 working with Dr. Richard F. Thompson. He then held faculty positions at the University of Michigan (1996-2012) and Texas A&M University (2012-2024), where he recently served as a University Distinguished Professor and Charles H. Gregory Chair of Liberal Arts in the Department of Psychological and Brain Sciences and Neuroscience program. In 2024, he returned to the University of Illinois as a Professor in Psychology and Director of the Beckman Institute for Advanced Science and Technology.
Research Interests
Neurobiology of learning and memory
Stress and emotion
Fear, anxiety, and psychopathology
Education
Biological Sciences (Neurobiology), PhD, University of Southern California
Psychology, BS, University of Illinois Urbana-Champaign
Additional Campus Affiliations
Director, Beckman Institute for Advanced Science and Technology
Professor, Beckman Institute for Advanced Science and Technology
Professor, Biomedical and Translational Sciences
External Links
Honors & Awards
2019 Gantt Medal, Pavlovian Society
Highlighted Publications
Totty, M. S., Tuna, T., Ramanathan, K. R., Jin, J., Peters, S. E., & Maren, S. (2023). Thalamic nucleus reuniens coordinates prefrontal-hippocampal synchrony to suppress extinguished fear. Nature communications, 14(1), Article 6565. https://doi.org/10.1038/s41467-023-42315-1
Binette, A. N., Liu, J., Bayer, H., Crayton, K. L., Melissari, L., Sweck, S. O., & Maren, S. (2023). Parvalbumin-Positive Interneurons in the Medial Prefrontal Cortex Regulate Stress-Induced Fear Extinction Impairments in Male and Female Rats. Journal of Neuroscience, 43(22), 4162-4173. https://doi.org/10.1523/JNEUROSCI.1442-22.2023
Vasudevan, K., Hassell, J. E., & Maren, S. (2024). Hippocampal Engrams and Contextual Memory. Advances in neurobiology, 38, 45-66. https://doi.org/10.1007/978-3-031-62983-9_4
Plas, S. L., Tuna, T., Bayer, H., Juliano, V. A. L., Sweck, S. O., Arellano Perez, A. D., Hassell, J. E., & Maren, S. (2024). Neural circuits for the adaptive regulation of fear and extinction memory. Frontiers in Behavioral Neuroscience, 18, Article 1352797. https://doi.org/10.3389/fnbeh.2024.1352797
Liu, J., Totty, M. S., Melissari, L., Bayer, H., & Maren, S. (2022). Convergent Coding of Recent and Remote Fear Memory in the Basolateral Amygdala. Biological Psychiatry, 91(9), 832-840. https://doi.org/10.1016/j.biopsych.2021.12.018
Recent Publications
Bayer, H., Hassell, J. E., Oleksiak, C. R., Garcia, G. M., Vaughan, H. L., Juliano, V. A. L., & Maren, S. (Accepted/In press). Pharmacological stimulation of infralimbic cortex after fear conditioning facilitates subsequent fear extinction. Neuropsychopharmacology, 49(13), 1951-1957. https://doi.org/10.1038/s41386-024-01961-9
Oleksiak, C. R., Plas, S. L., Carriaga, D., Vasudevan, K., Maren, S., & Moscarello, J. M. (2024). Ventral hippocampus mediates inter-trial responding in signaled active avoidance. Behavioural Brain Research, 470, Article 115071. https://doi.org/10.1016/j.bbr.2024.115071
Plas, S. L., Oleksiak, C. R., Pitre, C., Melton, C., Moscarello, J. M., & Maren, S. (2024). Acute stress yields a sex-dependent facilitation of signaled active avoidance in rats. Neurobiology of Stress, 31, Article 100656. https://doi.org/10.1016/j.ynstr.2024.100656
Plas, S. L., Tuna, T., Bayer, H., Juliano, V. A. L., Sweck, S. O., Arellano Perez, A. D., Hassell, J. E., & Maren, S. (2024). Neural circuits for the adaptive regulation of fear and extinction memory. Frontiers in Behavioral Neuroscience, 18, Article 1352797. https://doi.org/10.3389/fnbeh.2024.1352797
Vasudevan, K., Hassell, J. E., & Maren, S. (2024). Hippocampal Engrams and Contextual Memory. Advances in neurobiology, 38, 45-66. https://doi.org/10.1007/978-3-031-62983-9_4